Protein Cages: From Fundamentals to Advanced Applications
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Date
2022-05-11
Publication Type
Review Article
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yes
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Abstract
Proteins that self-assemble into polyhedral shell-like structures are useful molecular containers both in nature and in the laboratory. Here we review efforts to repurpose diverse protein cages, including viral capsids, ferritins, bacterial microcompartments, and designed capsules, as vaccines, drug delivery vehicles, targeted imaging agents, nanoreactors, templates for controlled materials synthesis, building blocks for higher-order architectures, and more. A deep understanding of the principles underlying the construction, function, and evolution of natural systems has been key to tailoring selective cargo encapsulation and interactions with both biological systems and synthetic materials through protein engineering and directed evolution. The ability to adapt and design increasingly sophisticated capsid structures and functions stands to benefit the fields of catalysis, materials science, and medicine.
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published
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Volume
122 (9)
Pages / Article No.
9145 - 9197
Publisher
American Chemical Society
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Organisational unit
03492 - Hilvert, Donald (emeritus) / Hilvert, Donald (emeritus)
Notes
Funding
844006 - Laboratory Evolution of Virus-likE pRotein cAGes for Eukaryotic mRNA delivery (EC)
19-2 FEL-29 - In vivo self-assembly of engineered protein nanocages for harnessing undesired protein aggregations (ETHZ)
19-2 FEL-29 - In vivo self-assembly of engineered protein nanocages for harnessing undesired protein aggregations (ETHZ)