Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis
OPEN ACCESS
Loading...
Author / Producer
Date
2022-12-15
Publication Type
Journal Article
ETH Bibliography
yes
Citations
Altmetric
OPEN ACCESS
Data
Abstract
The cerebral cortex contains billions of neurons, and their disorganization or misspecification leads to neurodevelopmental disorders. Understanding how the plethora of projection neuron subtypes are generated by cortical neural stem cells (NSCs) is a major challenge. Here, we focused on elucidating the transcriptional landscape of murine embryonic NSCs, basal progenitors (BPs), and newborn neurons (NBNs) throughout cortical development. We uncover dynamic shifts in transcriptional space over time and heterogeneity within each progenitor population. We identified signature hallmarks of NSC, BP, and NBN clusters and predict active transcriptional nodes and networks that contribute to neural fate specification. We find that the expression of receptors, ligands, and downstream pathway components is highly dynamic over time and throughout the lineage implying differential responsiveness to signals. Thus, we provide an expansive compendium of gene expression during cortical development that will be an invaluable resource for studying neural developmental processes and neurodevelopmental disorders.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
41 (24)
Pages / Article No.
Publisher
EMBO Press
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Cortical development; Lineage specification; Networks; Signaling pathways; Transcriptional landscape
Organisational unit
03791 - Iber, Dagmar / Iber, Dagmar
Notes
Funding
Related publications and datasets
Is supplemented by: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134688Is supplemented by: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134738Is supplemented by: https://ismara.unibas.ch/NeuroStemX