Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A
METADATA ONLY
Loading...
Author / Producer
Date
2020-07-14
Publication Type
Journal Article
ETH Bibliography
yes
Citations
Altmetric
METADATA ONLY
Data
Rights / License
Abstract
Characterization of the complex molecular scaffold of the marine polyketide natural product phormidolide A represents a challenge that has persisted for nearly two decades. In light of discordant results arising from recent synthetic and biosynthetic reports, a rigorous study of the configuration of phormidolide A was necessary. This report outlines a synergistic effort employing computational and anisotropic NMR investigation, that provided orthogonal confirmation of the reassigned side chain, as well as supporting a further correction of the C7 stereocenter. © 2020 The Royal Society of Chemistry
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
56 (55)
Pages / Article No.
7565 - 7568
Publisher
Royal Society of Chemistry
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Organisational unit
03980 - Piel, Jörn / Piel, Jörn