Reduced amygdala activity during aversive conditioning in human narcolepsy
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Date
2010
Publication Type
Journal Article
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yes
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Abstract
Narcolepsy with cataplexy is a sleep‐wake disorder caused by a loss of hypothalamic hypocretins. Here we assessed the time course of amygdala activation during aversive conditioning in unmedicated patients with narcolepsy. Unlike healthy matched control subjects, narcolepsy patients had no enhancement of amygdala response to conditioned stimuli and no increase in functional coupling between the amygdala and medial prefrontal cortex. These findings suggest that human narcolepsy is accompanied by abnormal emotional learning, and that, in line with animal data, the hypocretin system and the amygdala are involved in this process. ANN NEUROL 2010;67:394–398
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published
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67 (3)
Pages / Article No.
394 - 398
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Wiley
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03656 - Bösiger, Peter (emeritus)
Notes
Received 8 March 2009, Revised 10 August 2009, Accepted 14 September 2009, published online 2 October 2009.