Web-based analysis of the mouse transcriptome using Genevestigator
OPEN ACCESS
Downloads
Loading...
Author / Producer
Date
2006-06
Publication Type
Journal Article
ETH Bibliography
yes
Citations
Altmetric
OPEN ACCESS
Downloads
Data
Rights / License
Abstract
Background
Gene function analysis often requires a complex and laborious sequence of laboratory and computer-based experiments. Choosing an effective experimental design generally results from hypotheses derived from prior knowledge or experimentation. Knowledge obtained from meta-analyzing compendia of expression data with annotation libraries can provide significant clues in understanding gene and network function, resulting in better hypotheses that can be tested in the laboratory.
Description
Genevestigator is a microarray database and analysis system allowing context-driven queries. Simple but powerful tools allow biologists with little computational background to retrieve information about when, where and how genes are expressed. We manually curated and quality-controlled 3110 mouse Affymetrix arrays from public repositories. Data queries can be run against an annotation library comprising 160 anatomy categories, 12 developmental stage groups, 80 stimuli, and 182 genetic backgrounds or modifications. The quality of results obtained through Genevestigator is illustrated by a number of biological scenarios that are substantiated by other types of experimentation in the literature.
Conclusion
The Genevestigator-Mouse database effectively provides biologically meaningful results and can be accessed at https://www.genevestigator.ethz.ch.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
7
Pages / Article No.
311
Publisher
BioMed Central
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
DNA-MIKROARRAY TECHNOLOGIE; DATENBEHANDLUNG + DATENAUSWERTUNG (EXPERIMENTELLE BIOLOGIE); GENEXPRESSION (GENETIK); MURIDAE (ZOOLOGIE); DNA MICROARRAYS; DATA TREATMENT + DATA INTERPRETATION (EXPERIMENTAL BIOLOGY); GENE EXPRESSION (GENETICS); MURIDAE (ZOOLOGY); Sirt1 Expression; Public Repository; Mutant Surveyor; Response Viewer; Edinburgh Mouse Atlas Project
Organisational unit
03340 - Widmayer, Peter (emeritus) / Widmayer, Peter (emeritus)
03554 - Gruissem, Wilhelm (emeritus) / Gruissem, Wilhelm (emeritus)
02703 - Institut für Agrarwissenschaften / Institute of Agricultural Sciences