Changing Face of Vaccination in Immunocompromised Hosts
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Date
2014
Publication Type
Journal Article
ETH Bibliography
yes
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Abstract
Infection prevention is a key component of care and an important determinant of clinical outcomes in a diverse population of immunocompromised hosts. Vaccination remains a fundamental preventative strategy, and clear guidelines exist for the vaccination of immunocompromised individuals and close contacts. Unfortunately, adherence to such guidelines is frequently suboptimal, with consequent missed opportunities to prevent infection. Additionally, vaccination of immunocompromised individuals is known to produce responses inferior to those observed in immunocompetent hosts. Multiple factors contribute to this finding, and developing improved vaccination strategies for those at high risk of infectious complications remains a priority of care providers. Herein, we review potential factors contributing to vaccine outcomes, focusing on host immune responses, and propose a means for applying modern, innovative systems biology technology to model critical determinants of vaccination success. With influenza vaccine in solid organ transplants used as a case in point, novel means for stratifying individuals using a host “immunophenotype” are explored, and strategies for individualizing vaccine approaches tailored to safely optimize vaccine responses in those most at risk are discussed.
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Publication status
published
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Book title
Journal / series
Volume
16 (9)
Pages / Article No.
420
Publisher
Current Science
Event
Edition / version
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Date created
Subject
Vaccination; Transplant recipients; Immunomodulation; Individualized vaccine strategies; Mathematical models; Surrogates of vaccine efficacy; Systems biology; Computational models
Organisational unit
03699 - Stelling, Jörg / Stelling, Jörg
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.