Aiming for More Sustainable Cross-Coupling Chemistry by Employing Single-Atom Catalysis on Scale
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Date
2023-03-29
Publication Type
Journal Article
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yes
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Abstract
Scaling up syntheses from mg to kg quantities is a complex endeavor. Besides adapting laboratory protocols to industrial processes and equipment and thorough safety assessments, much attention is paid to the reduction of the process' environmental impact. For processes including transition metal catalyzed steps, e.g., cross-coupling chemistry, this impact strongly depends on the identity of the metal used. As such, a key approach is the replacement of single-use with reusable heterogeneous catalysts. Transition metal single-atom heterogeneous catalysts (SAC), a novel class of catalytic materials, might exhibit all the necessary properties to step up to this task. This article shall discuss current applications of SAC in cross-coupling chemistry from the point of a process chemist and shed light on the NCCR Catalysis contribution to the field. Investigations of the stability-activity-selectivity relationship of SACs in combination with early-stage life-cycle assessments (LCA) of potential processes lay the foundation for large-scale application tailored catalyst synthesis. Ultimately, prevailing challenges are highlighted, which need to be addressed in future research.
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published
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Journal / series
Volume
77 (3)
Pages / Article No.
127 - 131
Publisher
Swiss Chemical Society
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Subject
Cross-coupling reactions; Life-cycle assessment; Process chemistry; Single-atom catalysis; Sustainability
Organisational unit
09655 - Guillén Gosálbez, Gonzalo / Guillén Gosálbez, Gonzalo
Notes
Funding
180544 - NCCR Catalysis (phase I) (SNF)