BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling
OPEN ACCESS
Loading...
Author / Producer
Date
2020-11
Publication Type
Review Article
ETH Bibliography
yes
Citations
Altmetric
OPEN ACCESS
Data
Rights / License
Abstract
The K63-linkage specific deubiquitinase BRCC36 forms the core of two multi-subunit deubiquitination complexes: BRCA1-A and BRISC. BRCA1-A is recruited to DNA repair foci, edits ubiquitin signals on chromatin, and sequesters BRCA1 away from the site of damage, suppressing homologous recombination by limiting resection. BRISC forms a complex with metabolic enzyme SHMT2 and regulates the immune response, mitosis, and hematopoiesis. Almost two decades of research have revealed how BRCA1-A and BRISC use the same core of subunits to perform very distinct biological tasks.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
10 (11)
Pages / Article No.
1503
Publisher
MDPI
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
deubiquitination; BRCA1; DNA repair; immune regulation; BRCC36; SHMT2; RAP80; ubiquitin; SUMO
Organisational unit
02891 - ScopeM / ScopeM