Immunocytokines
A review of molecules in clinical development for cancer therapy
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Author / Producer
Date
2013
Publication Type
Journal Article
ETH Bibliography
yes
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OPEN ACCESS
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Abstract
The concept of therapeutically enhancing the immune system’s responsiveness to tumors is long standing. Several cytokines have been investigated in clinical trials for their therapeutic activity in cancer patients. However, substantial side effects and unfavorable pharmacokinetic properties have been a major drawback hampering the administration of therapeutically relevant doses. The use of recombinant antibody–cytokine fusion proteins promises to significantly enhance the therapeutic index of cytokines by targeting them to the site of disease. This review aims to provide a concise and complete overview of the preclinical data and clinical results currently available for all immunocytokines having reached clinical development.
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Publication status
published
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Book title
Journal / series
Volume
5 (Supplement 1)
Pages / Article No.
29 - 45
Publisher
Dove Medical Press
Event
Edition / version
Methods
Software
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Date collected
Date created
Subject
antibodies; cytokines; preclinical
Organisational unit
03463 - Neri, Dario (ehemalig) / Neri, Dario (former)