An antiviral trap made of protein nanofibrils and iron oxyhydroxide nanoparticles
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Date
2021-08
Publication Type
Journal Article
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yes
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Abstract
Minimizing the spread of viruses in the environment is the first defense line when fighting outbreaks and pandemics, but the current SARS-CoV-2 pandemic demonstrates how difficult this is on global scale, particularly in a sustainable and environmental-friendly way. Here we introduce and develop a sustainable and bio-degradable anti-viral filtration membrane composed of amyloid nanofibrils made from food-grade milk proteins and iron oxyhydroxide nanoparticles synthesized in-situ from iron salts by simple pH-tuning. Thus, all the membrane components are made of environmentally friendly, non-toxic and widely available materials. The membrane has outstanding efficacy against a broad range of viruses, including enveloped, non-enveloped, airborne and waterborne viruses, such as SARS-CoV-2, H1N1 (the influenza A virus strain responsible for the swine flu pandemic in 2009), and enterovirus 71 (EV71; a non-enveloped virus resistant to harsh conditions such as highly acidic pH), highlighting a possible role in fighting the current and future viral outbreaks and pandemics.
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published
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Book title
Journal / series
Volume
16
Pages / Article No.
918 - 925
Publisher
Nature
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Edition / version
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Software
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Date collected
Date created
Subject
Organisational unit
02891 - ScopeM / ScopeM
03857 - Mezzenga, Raffaele / Mezzenga, Raffaele
Notes
This is a post-peer-review, pre-copyedit version of an article published in Nature Nanotechnology. The final authenticated version is available online at: https://doi.org/10.1038/s41565-021-00920-5.