Simultaneous impedance spectroscopy and stimulation of human IPS-derived cardiac 3D spheroids in hanging-drop networks
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Date
2015
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Conference Paper
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Abstract
Here, we present electrical impedance spectroscopy (EIS) data of human iPS-derived cardiac 3D spheroids with electric stimulation integrated in a hanging drop network. Microscopy videos of the beating spheroids were correlated with synchronously obtained EIS recordings. For stimulation, the spheroid was exposed to a continuous sinusoidal electric field - in contrast to traditional pulse trains. This stimulating field was supplied via the same electrodes that were used for the EIS recordings. Our measurements revealed a beating frequency modulation upon tuning the stimulation signal amplitude.
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2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
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226 - 229
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IEEE
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28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
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03684 - Hierlemann, Andreas / Hierlemann, Andreas
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296257 - The Body-on-a-Chip (BoC) (EC)
142440 - The Body on a Chip - Human 3-D tissue analogues in microfluidic systems (SNF)
142440 - The Body on a Chip - Human 3-D tissue analogues in microfluidic systems (SNF)