Kryo-EM enthüllt Mechanismen viraler Replikationsstrategien
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Date
2025-10
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Review Article
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yes
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Abstract
Protein-primed DNA replication is an alternative replication mode solving the end-replication problem of canonical linear DNA replication. In the PRD1 bacteriophage, the ssDNA-binding protein P12 is a key player in this process. We resolved its structure via high-resolution cryo-EM, revealing a unique fold that enables cooperative filament formation and stabilises ssDNA replication intermediates. Our findings enhance the understanding of ssDNA-binding proteins and viral replication mechanisms.
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published
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31 (6)
Pages / Article No.
625 - 628
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Springer Spektrum
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An Erratum to this article was published on 29 October 2025
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Is referenced by: https://doi.org/10.1007/s12268-025-2595-5