How Influenza Virus Uses Host Cell Pathways during Uncoating
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Author / Producer
Date
2021-07
Publication Type
Review Article
ETH Bibliography
no
Citations
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Abstract
Influenza is a zoonotic respiratory disease of major public health interest due to its pandemic potential, and a threat to animals and the human population. The influenza A virus genome consists of eight single-stranded RNA segments sequestered within a protein capsid and a lipid bilayer envelope. During host cell entry, cellular cues contribute to viral conformational changes that promote critical events such as fusion with late endosomes, capsid uncoating and viral genome release into the cytosol. In this focused review, we concisely describe the virus infection cycle and highlight the recent findings of host cell pathways and cytosolic proteins that assist influenza uncoating during host cell entry.
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Publication status
published
External links
Editor
Book title
Journal / series
Volume
10 (7)
Pages / Article No.
1722
Publisher
MDPI
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
influenza; capsid uncoating; HDAC6; ubiquitin; EPS8; TNPO1; pandemic; M1; virus–host interaction
Organisational unit
09780 - Yamauchi, Yohei / Yamauchi, Yohei
Notes
Funding
856581 - Ubiquiti Chains in Viral Infections (EC)