Mitotic spindle (DIS)orientation and DISease: Cause or consequence?
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Date
2012-12
Publication Type
Review Article
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yes
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Abstract
Correct alignment of the mitotic spindle during cell division is crucial for cell fate determination, tissue organization, and development. Mutations causing brain diseases and cancer in humans and mice have been associated with spindle orientation defects. These defects are thought to lead to an imbalance between symmetric and asymmetric divisions, causing reduced or excessive cell proliferation. However, most of these disease-linked genes encode proteins that carry out multiple cellular functions. Here, we discuss whether spindle orientation defects are the direct cause for these diseases, or just a correlative side effect.
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published
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Journal / series
Volume
199 (7)
Pages / Article No.
1025 - 1035
Publisher
Rockefeller University Press
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Edition / version
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Software
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Organisational unit
03745 - Meraldi, Patrick (SNF-Professur) (ehem.)