Too big not to fail: emerging evidence for size-induced senescence
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Date
2024-06
Publication Type
Review Article
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yes
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Abstract
Cellular senescence refers to a permanent and stable state of cell cycle exit. This process plays an important role in many cellular functions, including tumor suppression. It was first noted that senescence is associated with increased cell size in the early 1960s; however, how this contributes to permanent cell cycle exit was poorly understood until recently. In this review, we discuss new findings that identify increased cell size as not only a consequence but also a cause of permanent cell cycle exit. We highlight recent insights into how increased cell size alters normal cellular physiology and creates homeostatic imbalances that contribute to senescence induction. Finally, we focus on the potential clinical implications of these findings in the context of cell cycle arrest-causing cancer therapeutics and speculate on how tumor cell size changes may impact outcomes in patients treated with these drugs.
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Publication status
published
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Journal / series
Volume
291 (11)
Pages / Article No.
2291 - 2305
Publisher
Wiley-Blackwell
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Edition / version
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Date collected
Date created
Subject
cell cycle; cell size; senescence
Organisational unit
09713 - Neurohr, Gabriel / Neurohr, Gabriel
Notes
Funding
212660 - Regulation and Functional Implications of Molecular Crowding in the Cytoplasm (SNF)
187003 - The impact of cell size on cell function in physiology and aging (SNF)
187003 - The impact of cell size on cell function in physiology and aging (SNF)