A new model for drug interactions and optimal drug dosing
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Author / Producer
Date
2005
Publication Type
Conference Paper
ETH Bibliography
yes
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Abstract
Drugs are routinely combined in anesthesia and pain management to obtain an enhancement of the desired effects. However, a parallel enhancement of the undesired effects might take place as well, resulting in a limited therapeutic usefulness. Therefore, when addressing the question of optimal drug combinations, side effects must be taken into account. We propose a new method to study drug interactions considering also their side effects and to identify optimal drug dosing. The model is consistent with clinical knowledge and can explain previously published experimental results, improving our understanding of the characteristics of drug combinations used in clinical practice.
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Publication status
published
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Book title
2005 IEEE Engineering in Medicine and Biology 27th Annual Conference
Journal / series
Volume
Pages / Article No.
2353 - 2356
Publisher
IEEE
Event
27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2005)
Edition / version
Methods
Software
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Date collected
Date created
Subject
Drug interactions; Optimal drug dosing; Pharmacodynamic modelling
Organisational unit
03416 - Morari, Manfred (emeritus)