Early life stress affects the miRNA cargo of epididymal extracellular vesicles in mouse†
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Date
2021-09
Publication Type
Journal Article
ETH Bibliography
yes
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Abstract
Sperm RNA can be modified by environmental factors and has been implicated in communicating signals about changes in a father's environment to the offspring. The small RNA composition of sperm could be changed during its final stage of maturation in the epididymis by extracellular vesicles (EVs) released by epididymal cells. We studied the effect of exposure to stress in early postnatal life on the transcriptome of epididymal EVs using a mouse model of transgenerational transmission. We found that the small RNA signature of epididymal EVs, particularly miRNAs, is altered in adult males exposed to postnatal stress. In some cases, these miRNA changes correlate with differences in the expression of their target genes in sperm and zygotes generated from that sperm. These results suggest that stressful experiences in early life can have persistent biological effects on the male reproductive tract that may in part be responsible for the transmission of the effects of exposure to the offspring.
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Publication status
published
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Book title
Journal / series
Volume
105 (3)
Pages / Article No.
593 - 602
Publisher
Oxford University Press
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
epigenetics; epididymis; epididymosomes; early life stress; extracellular vesicles; miR- NAs; sperm
Organisational unit
03518 - Mansuy, Isabelle / Mansuy, Isabelle
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
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