The structure of temperate phage–bacteria infection networks changes with the phylogenetic distance of the host bacteria
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Date
2018-11
Publication Type
Journal Article
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yes
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Abstract
With their ability to integrate into the bacterial chromosome and thereby transfer virulence or drug-resistance genes across bacterial species, temperate phage play a key role in bacterial evolution. Thus, it is paramount to understand who infects whom to be able to predict the movement of DNA across the prokaryotic world and ultimately the emergence of novel (drug-resistant) pathogens. We empirically investigated lytic infection patterns among Vibrio spp. from distinct phylogenetic clades and their derived temperate phage. We found that across distantly related clades, infections occur preferentially within modules of the same clade. However, when the genetic distance of the host bacteria decreases, these clade-specific infections disappear. This indicates that the structure of temperate phage–bacteria infection networks changes with the phylogenetic distance of the host bacteria.
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published
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Journal / series
Volume
14 (11)
Pages / Article No.
20180320
Publisher
Royal Society
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Subject
Vibrio; temperate phage; infection networks
Organisational unit
09497 - Hall, Alex / Hall, Alex