Metabolic landscape of the male mouse gut identifies different niches determined by microbial activities
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Date
2023-06
Publication Type
Journal Article
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yes
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Abstract
Distinct niches of the mammalian gut are populated by diverse microbiota, but the contribution of spatial variation to intestinal metabolism remains unclear. Here we present a map of the longitudinal metabolome along the gut of healthy colonized and germ-free male mice. With this map, we reveal a general shift from amino acids in the small intestine to organic acids, vitamins and nucleotides in the large intestine. We compare the metabolic landscapes in colonized versus germ-free mice to disentangle the origin of many metabolites in different niches, which in some cases allows us to infer the underlying processes or identify the producing species. Beyond the known impact of diet on the small intestinal metabolic niche, distinct spatial patterns suggest specific microbial influence on the metabolome in the small intestine. Thus, we present a map of intestinal metabolism and identify metabolite-microbe associations, which provide a basis to connect the spatial occurrence of bioactive compounds to host or microorganism metabolism.
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published
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Journal / series
Volume
5 (6)
Pages / Article No.
968 - 980
Publisher
Nature
Event
Edition / version
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Software
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Date collected
Date created
Subject
Gastrointestinal models; Metabolomics; Microbiome; Multicellular systems
Organisational unit
08839 - Zamboni, Nicola (Tit.-Prof.)
03713 - Sauer, Uwe / Sauer, Uwe
09583 - Sunagawa, Shinichi / Sunagawa, Shinichi
Notes
Funding
177164 - Intermicrobial and host-microbial interactions that determine the trajectory of mammalian microbial colorization in early life (SNF)