A mechanism of deficient interregional neural communication in schizophrenia
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Date
2015-05
Publication Type
Journal Article
ETH Bibliography
no
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Abstract
Cognitive interference control is disrupted in schizophrenia (SZ). Neuroimaging studies relate interference control to
4–7 Hz (theta) neural activity in a network spanning prefrontal, anterior cingulate (ACC), and parietal cortices. The
mechanism of communication in this network and how it is disrupted in schizophrenia are unclear. Behavioral perfor-
mance and EEG theta oscillations were examined in a Stroop color-word interference task in 17 healthy controls (HC)
and 14 SZ patients. Color-word incongruence induced less theta power increase in SZ than in HC around 400 ms and
600–900 ms after word onset in ACC, left middle frontal gyrus (MFG), and inferior parietal regions. Coupling of ACC
theta phase to MFG gamma amplitude, indexing interregional communication, was weaker in SZ than in HC. Results
suggest ACC-MFG theta power modulation as a mechanism of interference control that supports executive function and
is disrupted in schizophrenia.
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published
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Journal / series
Volume
52 (5)
Pages / Article No.
648 - 656
Publisher
Wiley-Blackwell
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Edition / version
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Software
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Date collected
Date created
Subject
Stroop; Interference control; Schizophrenia; Theta oscillations; EEG
Organisational unit
09871 - Meissner, Sarah / Meissner, Sarah