Advances in genome editing through control of DNA repair pathways
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Author / Producer
Date
2019-12
Publication Type
Review Article
ETH Bibliography
yes
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OPEN ACCESS
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Abstract
Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage. Advancements in genome editing take advantage of these pathways to produce permanent genetic changes. Despite recent improvements, genome editing can produce diverse outcomes that can introduce risks in clinical applications. Although homology-directed repair is attractive for its ability to encode precise edits, it is particularly difficult in human cells. Here we discuss the DNA repair pathways that underlie genome editing and strategies to favour various outcomes.
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Publication status
published
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Book title
Journal / series
Volume
21 (12)
Pages / Article No.
1468 - 1478
Publisher
Nature
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
CRISPR-Cas9 genome editing; DNA damage and repair; Embryogenesis
Organisational unit
09635 - Corn, Jacob / Corn, Jacob
09635 - Corn, Jacob / Corn, Jacob
09635 - Corn, Jacob / Corn, Jacob
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
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