Impedance-based detection of Schistosoma mansoni larvae viability for drug screening
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Date
2018-02
Publication Type
Conference Paper
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yes
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Abstract
Human schistosomiasis is a neglected tropical disease caused by trematodes, affecting almost 250 million people worldwide. For the past 30 years, treatment has relied on the large-scale administration of praziquantel. However, concerns regarding the appearance of drug-resistance parasites require efforts in identifying novel classes of suitable drugs against schistosomiasis. The current drug screening system is manual, slow and subjective. We present here a microfluidic platform capable of detecting changes in viability of Schistosoma mansoni larvae (Newly Transformed Schistosomula, NTS). This platform could serve as a pre-screening tool for the identification of drug candidates. It is composed of a pair of coplanar electrodes integrated in a microfluidic channel for the detection and quantification of NTS motility. Comparison of viability detection by using our platform with the standard visual evaluation shows that our method is able to reliably detect viable and non-viable NTS at high sensitivity, also in case of low-motility parasites, while enabling a 10 fold decrease in sample consumption.
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published
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Book title
2017 IEEE Biomedical Circuits and Systems Conference (BioCAS)
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Pages / Article No.
8325227
Publisher
IEEE
Event
2017 IEEE Biomedical Circuits and Systems Conference (BioCAS)
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Subject
schistosomiasis; Schistosoma mansoni; impedance analysis; drug screening
Organisational unit
03684 - Hierlemann, Andreas / Hierlemann, Andreas