Mit oclone2: an R pac kag e f or elucidating clonal structure in single-cell RNA-sequencing data using mit oc hondrialvar iants
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Date
2024-09
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Journal Article
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Abstract
Clonal cell population dynamics play a critical role in both disease and de v elopment. Due to high mitochondrial mutation rates under both healthy and diseased conditions, mitochondrial genomic variability is a particularly useful resource in facilitating the identification of clonal population str uct ure. Here we present mitoClone2, an all-inclusive R package allowing for the identification of clonal populations through integration of mitochondrial heteroplasmic variants discovered from single-cell sequencing experiments. Our package streamlines the investigation of this phenomenon by providing: built-in compatibility with commonly used tools for the delineation of clonal str uct ure, the ability to directly use multiple x ed BAM files as input, annotations for both human and mouse mitochondrial genomes, and helper functions for calling , filtering , clustering, and visualizing variants.
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published
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Volume
6 (3)
Pages / Article No.
Publisher
Oxford University Press