Which ‘dose rate’ definition describes the FLASH sparing effect for scanned proton beams? A meta-analysis of skin murine data
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Date
2025-12
Publication Type
Journal Article
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yes
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Abstract
We compiled preclinical proton PBS skin toxicity data to assess how various dose rate definitions (field, average, and dose average) explain the FLASH sparing effect. Only average dose rate (ADR), accounting for ‘effective irradiation time,’ reliably describes it. We identified high-dose and ADR regions where the effect was consistently observed.
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published
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Volume
213
Pages / Article No.
111206
Publisher
Elsevier
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Subject
FLASH effect; Dose rate metric; Dose rate threshold; Skin toxicity