Kinetic vs. thermodynamic control of β-functionalized cyclic ketones: a theoretical investigation of regioselective formation of enolates
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Date
2022-11-21
Publication Type
Journal Article
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yes
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Abstract
Thermodynamic- and kinetic-controlled deprotonation of symmetric and asymmetric ketones is a wellknown process that leads to the formation of enolates, one of the most important intermediates in organic chemistry. To the best of our knowledge, no studies have been specifically reported on beta-functionalized ketones in which regioselective formation of enolates could be less obvious and intuitive with respect to that observed in the most familiar alpha-functionalized analogues. Here we report a theoretical study on the effect of a set of kinetic parameters on the regioselctivity of beta-functionalized cyclic ketones 1-6. This study has shed light on some unexplained behaviours reported in the literature, high-lighting the importance of non-covalent interactions in regiocontrolled processes.
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published
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Journal / series
Volume
9 (22)
Pages / Article No.
6205 - 6212
Publisher
Royal Society of Chemistry