Self-Sorting Collagen Heterotrimers
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Date
2024-01-24
Publication Type
Journal Article
ETH Bibliography
yes
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Abstract
Nature uses elaborate methods to control protein assembly, including that of heterotrimeric collagen. Here, we established design principles for the composition and register-selective assembly of synthetic collagen heterotrimers. The assembly code enabled the self-sorting of eight different strands into three─out of 512 possible─triple helices via complementary (4S)-aminoproline and aspartate residues. Native ESI-MS corroborated the specific assembly into coexisting heterotrimers.
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Publication status
published
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Book title
Journal / series
Volume
146 (3)
Pages / Article No.
1789 - 1793
Publisher
American Chemical Society
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Organisational unit
03940 - Wennemers, Helma / Wennemers, Helma
03430 - Zenobi, Renato / Zenobi, Renato
Notes
Funding
207505 - Synthetic Collagen (SNF)
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