Mitotic disassembly and reassembly of nuclear pore complexes
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Author / Producer
Date
2021-12
Publication Type
Review Article
ETH Bibliography
yes
Citations
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Abstract
Nuclear pore complexes (NPCs) are huge protein assemblies within the nuclear envelope (NE) that serve as selective gates for macromolecular transport between nucleus and cytoplasm. When higher eukaryotic cells prepare for division, they rapidly disintegrate NPCs during NE breakdown such that nuclear and cytoplasmic components mix to enable the formation of a cytoplasmic mitotic spindle. At the end of mitosis, reassembly of NPCs is coordinated with the establishment of the NE around decondensing chromatin. We review recent progress on mitotic NPC disassembly and reassembly, focusing on vertebrate cells. We highlight novel mechanistic insights into how NPCs are rapidly disintegrated into conveniently reusable building blocks, and put divergent models of (post-)mitotic NPC assembly into a spatial and temporal context.
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Publication status
published
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Editor
Book title
Journal / series
Volume
31 (12)
Pages / Article No.
1019 - 1033
Publisher
Elsevier
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
mitosis; nuclear pore complex; nuclear envelope breakdown; nuclear reassembly
Organisational unit
03543 - Kutay, Ulrike / Kutay, Ulrike
Notes
Funding
184801 - Molecular Mechanisms of Nuclear Envelope Breakdown (SNF)