Simulation Frameworks for Morphogenetic Problems
OPEN ACCESS
Author / Producer
Date
2015
Publication Type
Other Journal Item
ETH Bibliography
yes
Citations
Altmetric
OPEN ACCESS
Data
Rights / License
Abstract
Morphogenetic modelling and simulation help to understand the processes by which the form and shapes of organs (organogenesis) and organisms (embryogenesis) emerge. This requires two mutually coupled entities: the biomolecular signalling network and the tissue. Whereas the modelling of the signalling has been discussed and used in a multitude of works, the realistic modelling of the tissue has only started on a larger scale in the last decade. Here, common tissue modelling techniques are reviewed. Besides the continuum approach, the principles and main applications of the spheroid, vertex, Cellular Potts, Immersed Boundary and Subcellular Element models are discussed in detail. In recent years, many software frameworks, implementing the aforementioned methods, have been developed. The most widely used frameworks and modelling markup languages and standards are presented.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
3 (2)
Pages / Article No.
197 - 221
Publisher
MDPI
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Cell-based modelling; Computational morphogenesis; Computational biology
Organisational unit
03791 - Iber, Dagmar / Iber, Dagmar