Group A Streptococcus strains causing meningitis without distinct invasive phenotype
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Date
2024-02
Publication Type
Journal Article
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Abstract
Group A streptococcal (GAS; aka Streptococcus pyogenes) meningitis is a fulminant disease associated with high morbidity and mortality. To elucidate the mechanisms underlying the invasiveness of GAS in meningitis, we compared GAS isolates derived from five cases of meningitis to otitis and colonizing isolates. We did not observe differences in adherence to and invasion of human brain microvascular endothelial cells, virulence factors activity, or barrier disruption. Whole genome sequencing did not reveal particular invasiveness traits. Most patients previously suffered from otitis media suggesting that meningitis likely resulted from a continuous spread of the infection rather than being attributable to changes in the pathogen's virulence.
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published
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Volume
13 (1)
Pages / Article No.
Publisher
Wiley
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Subject
Group A Streptococcus; Meningitis; Virulence determinants
Organisational unit
09497 - Hall, Alex / Hall, Alex
Notes
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung. Grant Numbers: 310030_204343, 31003A_169962