Genotoxic Agents: An Unexpected Effect on Healthy Epithelia
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Date
2020
Publication Type
Journal Article
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yes
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Abstract
DNA cross-linking agents are common chemotherapeutics for cancer treatment, but their effect on normal cells is largely unknown. In this issue of Developmental Cell, Seldin and Macara (2020) show that such compounds induce epithelial hyperplasia and stem cell fate mis-specification in a non-cell-autonomous manner via inflammasome activation in dermal fibroblasts. © 2020 Elsevier
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published
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Journal / series
Volume
55 (5)
Pages / Article No.
515 - 517
Publisher
Cell Press
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Organisational unit
03520 - Werner, Sabine (emeritus) / Werner, Sabine (emeritus)