Biology, vulnerabilities and clinical applications of circulating tumour cells
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Author / Producer
Date
2023-02
Publication Type
Review Article
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yes
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Abstract
In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading to new fields of research and fostering the promise for paradigm-changing, liquid biopsy-based clinical applications. Analysis of CTCs has revealed distinct biological phenotypes, including the presence of CTC clusters and the interaction between CTCs and immune or stromal cells, impacting metastasis formation and providing new insights into cancer vulnerabilities. Here we review the progress made in understanding biological features of CTCs and provide insight into exploiting these developments to design future clinical tools for improving the diagnosis and treatment of cancer.
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published
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Journal / series
Volume
23 (2)
Pages / Article No.
95 - 111
Publisher
Nature
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Software
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Organisational unit
09736 - Aceto, Nicola / Aceto, Nicola
Notes
Funding
101001652 - Tumor-lock: forbid the generation of circulating tumor cells (EC)
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801159-21 - Breast cancer metastasis TO the Bone with a first-of-its-kind 3D device that recapitulates physiological tissue-level complexity. (EC)
212183 - CRISPR screen for immunotherapy sensitizers in humanized circulating tumor cell xenografts (SNF)