Travelling under pressure-hypoxia and shear stress in the metastatic journey
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Author / Producer
Date
2023-10
Publication Type
Review Article
ETH Bibliography
yes
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Abstract
Cancer cell invasion, intravasation and survival in the bloodstream are early steps of the metastatic process, pivotal to enabling the spread of cancer to distant tissues. Circulating tumor cells (CTCs) represent a highly selected subpopulation of cancer cells that tamed these critical steps, and a better understanding of their biology and driving molecular principles may facilitate the development of novel tools to prevent metastasis. Here, we describe key research advances in this field, aiming at describing early metastasis-related processes such as collective invasion, shedding, and survival of CTCs in the bloodstream, paying particular attention to microenvironmental factors like hypoxia and mechanical stress, considered as important influencers of the metastatic journey.
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Publication status
published
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Book title
Journal / series
Volume
40 (5)
Pages / Article No.
375 - 394
Publisher
Springer
Event
Edition / version
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Software
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Date collected
Date created
Subject
Metastasis; Circulating tumor cell (CTC); Hypoxia; Hypoxia-inducible factors; Shear stress
Organisational unit
09736 - Aceto, Nicola / Aceto, Nicola
Notes
Funding
101001652 - Tumor-lock: forbid the generation of circulating tumor cells (EC)
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801159-21 - Breast cancer metastasis TO the Bone with a first-of-its-kind 3D device that recapitulates physiological tissue-level complexity. (EC)
212183 - CRISPR screen for immunotherapy sensitizers in humanized circulating tumor cell xenografts (SNF)
192614 - Exploring the molecular mechanism of HIF-2alpha-mediated pexophagy to identify novel therapeutic targets for the treatment of clear cell renal cell carcinoma (ccRCC) and hepatocellular carcinoma (HCC) (SNF)