Self-sustained closed respiratory loop in chronic obstructive pulmonary disease in real life—A perspective
OPEN ACCESS
Loading...
Author / Producer
Date
2025-10-28
Publication Type
Review Article
ETH Bibliography
yes
OPEN ACCESS
Data
Abstract
Chronic obstructive pulmonary disease (COPD) is a major public health issue impacting healthcare worldwide. COPD leads to a constant decline in respiratory function and death. Oxygen therapy plays an important part in managing COPD; however, the available solutions often remain inadequate in adapting to patients’ fluctuating oxygen demands in the real world. We propose a conceptual approach based on closed-loop automated respiratory control (CLARC) that integrates a wearable oxygen delivery system designed to provide personalized and adaptive oxygen therapy. CLARC integrates printed biosensors, wearable electronics, and a miniaturized unitized reversible fuel cell (uRFC) to generate and regulate oxygen supply sustainably and in accordance with a patient’s real-world demand, such as during activity or rest. Further, this perspective discusses the full project development chain ranging from ideation to clinical testing to reach the aim of long-term home-care applications. CLARC is a transdisciplinary, evolved concept with the potential to reshape state-of-the-art COPD management.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
1 (9)
Pages / Article No.
100157
Publisher
Cell Press
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
printed biosensors; wearable electronics; wearable oxygen delivery system; miniaturized unitized reversible fuel cell; chronic obstructive pulmonary disease; closed-loop
Organisational unit
08827 - Goldhahn, Jörg (Tit.-Prof.)