Vaccine-enhanced competition permits rational bacterial strain replacement in the gut

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Author / Producer

Woller, Aurore Rocker, Andrea

Date

2025-04-04

Publication Type

Journal Article

ETH Bibliography

yes

Citations

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Rights / License

Abstract

Colonization of the intestinal lumen precedes invasive infection for a wide range of enteropathogenic and opportunistic pathogenic bacteria. We show that combining oral vaccination with engineered or selected niche-competitor strains permits pathogen exclusion and strain replacement in the mouse gut lumen. This approach can be applied either prophylactically to prevent invasion of nontyphoidal Salmonella strains, or therapeutically to displace an established Escherichia coli. Both intact adaptive immunity and metabolic niche competition are necessary for efficient vaccine-enhanced competition. Our findings imply that mucosal antibodies have evolved to work in the context of gut microbial ecology by influencing the outcome of competition. This has broad implications for the elimination of pathogenic and antibiotic-resistant bacterial reservoirs and for rational microbiota engineering.

Permanent link

http://hdl.handle.net/20.500.11850/732821

Publication status

published

External links

https://doi.org/10.1126/science.adp5011 north_east

Editor

Book title

Journal / series

Volume

388 (6742)

Pages / Article No.

74 - 81

Publisher

AAAS

Event

Edition / version

Methods

Software

Geographic location

Date collected

Date created

Subject

Organisational unit

03589 - Hardt, Wolf-Dietrich / Hardt, Wolf-Dietrich check_circle
09640 - Wetter Slack, Emma / Wetter Slack, Emma check_circle

Notes

Funding

180953 - Self-assembling glycoprotein nanoparticle vaccines (SNF)
185128 - How to resolve dysbiosis: Understanding and manipulating mechanisms of T cell-microbiota crosstalk (SNF)
865730 - Systems-level novel understanding of anti-gylcan immunity (EC)
-180575 - NCCR Microbiomes SNF (SNF)
180575 - Flexibility Grant Noa Barak-Gavish (SNF)

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