Antibody response to a third SARS‐CoV‐2 vaccine dose in recipients of an allogeneic haematopoietic cell transplantation
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Date
2023-04
Publication Type
Journal Article
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yes
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Abstract
Allogeneic haematopoietic cell transplantation (allo-HCT) recipients show impaired antibody (Ab) response to a standard two-dose vaccination against severe acute respiratory syndrome coronavirus-2 and currently a third dose is recommended as part of the primary vaccination regimen. By assessing Ab titres 1 month after a third mRNA vaccine dose in 74 allo-HCT recipients we show sufficient neutralisation ac-tivity in 77% of the patients. Discontinuation of immunosuppression before the third vaccine led to serological responses in 50% of low responders to two vaccinations. Identifying factors that might contribute to better vaccine responses in allo-HCT recipients is critical to optimise current vaccination strategies.
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published
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Journal / series
Volume
201 (1)
Pages / Article No.
58 - 63
Publisher
Wiley
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Date created
Subject
allogeneic haematopoietic cell transplantation; severe acute respiratory syndrome coronavirus-2 (SARS- CoV- 2); vaccine response
Organisational unit
02803 - Collegium Helveticum / Collegium Helveticum