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Multimaterial powder bed fusion techniques
(2022)Rapid Prototyping JournalPurpose This study aims to provide a comprehensive overview of the current state of the art in powder bed fusion (PBF) techniques for additive manufacturing of multiple materials. It reviews the emerging technologies in PBF multimaterial printing and summarizes the latest simulation approaches for modeling them. The topic of “multimaterial PBF techniques” is still very new, undeveloped, and of interest to academia and industry on many ...Review Article -
Three-dimensional gravity modelling of a Quaternary overdeepening fill in the Bern area of Switzerland discloses two stages of glacial carving
(2022)Scientific ReportsThe geometry of glacial overdeepenings on the Swiss Plateau close to Bern was inferred through a combination of gravity data with a 3D gravity modelling software. The target overdeepenings have depths between 155 and > 270 m and widths between 860 and 2400 m. The models show incisions characterized by U-shaped cross-sectional geometries and steep to over-steepened lateral flanks. Existing stratigraphic data reveals that the overdeepenings ...Journal Article -
Silica nanoparticles with encapsulated DNA (SPED) to trace the spread of pathogens in healthcare
(2022)Antimicrobial Resistance and Infection ControlBackground To establish effective infection control protocols, understanding pathogen transmission pathways is essential. Non-infectious surrogate tracers may safely explore these pathways and challenge pre-existing assumptions. We used silica nanoparticles with encapsulated DNA (SPED) for the first time in a real-life hospital setting to investigate potential transmission routes of vancomycin-resistant enterococci in the context of a ...Journal Article -
Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies
(2022)Acta Neuropathologica CommunicationsThe cellular alterations of the hippocampus lead to memory decline, a shared symptom between Alzheimer’s disease (AD) and dementia with Lewy Bodies (DLB) patients. However, the subregional deterioration pattern of the hippocampus differs between AD and DLB with the CA1 subfield being more severely affected in AD. The activation of microglia, the brain immune cells, could play a role in its selective volume loss. How subregional microglia ...Journal Article -
Virtual reality reduces COVID-19 vaccine hesitancy in the wild: a randomized trial
(2022)Scientific ReportsVaccine hesitancy poses one of the largest threats to global health. Informing people about the collective benefit of vaccination has great potential in increasing vaccination intentions. This research investigates the potential for engaging experiences in immersive virtual reality (VR) to strengthen participants’ understanding of community immunity, and therefore, their intention to get vaccinated. In a pre-registered lab-in-the-field ...Journal Article -
Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational study
(2022)Human GenomicsBackground Genome-wide association studies have identified statistical associations between various diseases, including cancers, and a large number of single-nucleotide polymorphisms (SNPs). However, they provide no direct explanation of the mechanisms underlying the association. Based on the recent discovery that changes in three-dimensional genome organization may have functional consequences on gene regulation favoring diseases, we ...Journal Article -
Microbes contribute to setting the ocean carbon flux by altering the fate of sinking particulates
(2022)Nature CommunicationsSinking particulate organic carbon out of the surface ocean sequesters carbon on decadal to millennial timescales. Predicting the particulate carbon flux is therefore critical for understanding both global carbon cycling and the future climate. Microbes play a crucial role in particulate organic carbon degradation, but the impact of depth-dependent microbial dynamics on ocean-scale particulate carbon fluxes is poorly understood. Here we ...Journal Article -
120 years of georesources research in Switzerland: the Swiss Geotechnical Commission (1899-2018)
(2022)Swiss Journal of GeosciencesGeological surveys have a wide range of tasks for their countries: to map the geology and to assess the georesources potential for metallic ores, industrial minerals, geothermal energy, fossil fuels, aggregates and groundwater. In Europe, most countries founded geological surveys around the mid-nineteenth century in order to create an overview of the geological resources they wanted to exploit. In Switzerland, at that time, the industrial ...Journal Article -
Firm bankruptcies and start-up activity in Switzerland during the COVID-19 crisis
(2022)Swiss Journal of Economics and StatisticsThis paper examines the incidence of firm bankruptcies and start-ups in Switzerland based on unique register data. We propose to assess the frequency of bankruptcies over time using the concept of excess mortality. During the COVID-19 crisis in 2020 and the first half of 2021, bankruptcy rates were substantially lower as compared to the pre-crisis period. This holds across most industries and regions. The Great Recession and the Swiss ...Journal Article -
Unveiling bulk and surface radiation forces in a dielectric liquid
(2022)Light: Science & ApplicationsPrecise control over light-matter interactions is critical for many optical manipulation and material characterization methodologies, further playing a paramount role in a host of nanotechnology applications. Nonetheless, the fundamental aspects of interactions between electromagnetic fields and matter have yet to be established unequivocally in terms of an electromagnetic momentum density. Here, we use tightly focused pulsed laser beams ...Journal Article