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dc.contributor.author
Madani, Indira
dc.contributor.author
Lomax, Antony J.
dc.contributor.author
Albertini, Francesca
dc.contributor.author
Trnková, Petra
dc.contributor.author
Weber, Damien C.
dc.date.accessioned
2019-10-08T16:19:14Z
dc.date.available
2017-06-11T17:36:21Z
dc.date.available
2019-10-08T16:19:14Z
dc.date.issued
2015
dc.identifier.other
10.1186/s13014-015-0384-x
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/101095
dc.identifier.doi
10.3929/ethz-b-000101095
dc.description.abstract
Background Newly diagnosed WHO grade II-III or any WHO grade recurrent meningioma exhibit an aggressive behavior and thus are considered as high- or intermediate risk tumors. Given the unsatisfactory rates of disease control and survival after primary or adjuvant radiation therapy, optimization of treatment strategies is needed. We investigated the potential of dose-painting intensity-modulated proton beam-therapy (IMPT) for intermediate- and high-risk meningioma. Material and methods Imaging data from five patients undergoing proton beam-therapy were used. The dose-painting target was defined using [68]Ga-[1,4,7,10-tetraazacyclododecane tetraacetic acid]– d-Phe1,Tyr3-octreotate ([68]Ga-DOTATATE)-positron emission tomography (PET) in target delineation. IMPT and photon intensity-modulated radiation therapy (IMRT) treatment plans were generated for each patient using an in-house developed treatment planning system (TPS) supporting spot-scanning technology and a commercial TPS, respectively. Doses of 66 Gy (2.2 Gy/fraction) and 54 Gy (1.8 Gy/fraction) were prescribed to the PET-based planning target volume (PTVPET) and the union of PET- and anatomical imaging-based PTV, respectively, in 30 fractions, using simultaneous integrated boost. Results Dose coverage of the PTVsPET was equally good or slightly better in IMPT plans: dose inhomogeneity was 10 ± 3% in the IMPT plans vs. 13 ± 1% in the IMRT plans (p = 0.33). The brain Dmean and brainstem D50 were small in the IMPT plans: 26.5 ± 1.5 Gy(RBE) and 0.002 ± 0.0 Gy(RBE), respectively, vs. 29.5 ± 1.5 Gy (p = 0.001) and 7.5 ± 11.1 Gy (p = 0.02) for the IMRT plans, respectively. The doses delivered to the optic structures were also decreased with IMPT. Conclusions Dose-painting IMPT is technically feasible using currently available planning tools and resulted in dose conformity of the dose-painted target comparable to IMRT with a significant reduction of radiation dose delivered to the brain, brainstem and optic apparatus. Dose escalation with IMPT may improve tumor control and decrease radiation-induced toxicity.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Intensity-modulated proton beam-therapy
en_US
dc.subject
Dose painting
en_US
dc.subject
PET
en_US
dc.subject
Simultaneous integrated boost
en_US
dc.subject
Meningioma
en_US
dc.title
Dose-painting intensity-modulated proton therapy for intermediate- and high-risk meningioma
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2015-03-30
ethz.journal.title
Radiation Oncology
ethz.journal.volume
10
en_US
ethz.pages.start
72
en_US
ethz.size
7 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
005576799
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T17:37:18Z
ethz.source
ECIT
ethz.identifier.importid
imp593653317c04065627
ethz.ecitpid
pub:158747
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-17T09:23:18Z
ethz.rosetta.lastUpdated
2019-10-08T16:19:28Z
ethz.rosetta.versionExported
true
ethz.COinS
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