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dc.contributor.author
Barbier de Reuille, Pierre
dc.contributor.author
Routier-Kierzkowska, Anne-Lise
dc.contributor.author
Kierzkowski, Daniel
dc.contributor.author
Bassel, George W.
dc.contributor.author
Schüpbach, Thierry
dc.contributor.author
Tauriello, Gerardo
dc.contributor.author
Bajpai, Namrata
dc.contributor.author
Strauss, Sören
dc.contributor.author
Weber, Alain
dc.contributor.author
Kiss, Annamaria
dc.contributor.author
Burian, Agata
dc.contributor.author
Hofhuis, Hugo
dc.contributor.author
Sapala, Aleksandra
dc.contributor.author
Lipowczan, Marcin
dc.contributor.author
Heimlicher, Maria B.
dc.contributor.author
Robinson, Sarah
dc.contributor.author
Bayer, Emmanuelle M.
dc.contributor.author
Basler, Konrad
dc.contributor.author
Koumoutsakos, Petros
dc.contributor.author
Roeder, Adrienne H.K.
dc.contributor.author
Aegerter-Wilmsen, Tinri
dc.contributor.author
Nakayama, Naomi
dc.contributor.author
Tsiantis, Miltos
dc.contributor.author
Hay, Angela
dc.contributor.author
Kwiatkowska, Dorota
dc.contributor.author
Xenarios, Ioannis
dc.contributor.author
Kuhlemeier, Cris
dc.contributor.author
Smith, Richard S.
dc.date.accessioned
2018-09-11T13:13:27Z
dc.date.available
2017-06-11T17:44:53Z
dc.date.available
2018-09-11T13:13:27Z
dc.date.issued
2015-05
dc.identifier.other
10.7554/eLife.05864
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/101393
dc.identifier.doi
10.3929/ethz-b-000101393
dc.description.abstract
Morphogenesis emerges from complex multiscale interactions between genetic and mechanical processes. To understand these processes, the evolution of cell shape, proliferation and gene expression must be quantified. This quantification is usually performed either in full 3D, which is computationally expensive and technically challenging, or on 2D planar projections, which introduces geometrical artifacts on highly curved organs. Here we present MorphoGraphX (www.MorphoGraphX.org), a software that bridges this gap by working directly with curved surface images extracted from 3D data. In addition to traditional 3D image analysis, we have developed algorithms to operate on curved surfaces, such as cell segmentation, lineage tracking and fluorescence signal quantification. The software's modular design makes it easy to include existing libraries, or to implement new algorithms. Cell geometries extracted with MorphoGraphX can be exported and used as templates for simulation models, providing a powerful platform to investigate the interactions between shape, genes and growth.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
eLife Sciences Publications
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
MorphoGraphX: A platform for quantifying morphogenesis in 4D
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
eLife
ethz.journal.volume
4
en_US
ethz.pages.start
e05864
en_US
ethz.size
20 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
007613147
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::03499 - Koumoutsakos, Petros / Koumoutsakos, Petros
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::03499 - Koumoutsakos, Petros / Koumoutsakos, Petros
ethz.date.deposited
2017-06-11T17:45:47Z
ethz.source
ECIT
ethz.identifier.importid
imp59365337f18fd33645
ethz.ecitpid
pub:159193
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-14T20:33:51Z
ethz.rosetta.lastUpdated
2018-11-08T01:57:52Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=MorphoGraphX:%20A%20platform%20for%20quantifying%20morphogenesis%20in%204D&rft.jtitle=eLife&rft.date=2015-05&rft.volume=4&rft.spage=e05864&rft.au=Barbier%20de%20Reuille,%20Pierre&Routier-Kierzkowska,%20Anne-Lise&Kierzkowski,%20Daniel&Bassel,%20George%20W.&Sch%C3%BCpbach,%20Thierry&rft.genre=article&
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