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dc.contributor.author
Melo, Vanessa Weber de
dc.contributor.author
Ali, Hanan Sheikh
dc.contributor.author
Freise, Jona
dc.contributor.author
Kühnert, Denise
dc.contributor.author
Essbauer, Sandra
dc.contributor.author
Mertens, Marc
dc.contributor.author
Wanka, Konrad M.
dc.contributor.author
Drewes, Stephan
dc.contributor.author
Ulrich, Rainer G.
dc.contributor.author
Heckel, Gerald
dc.date.accessioned
2019-07-02T14:42:39Z
dc.date.available
2017-06-11T18:04:37Z
dc.date.available
2019-07-02T14:42:39Z
dc.date.issued
2015-07
dc.identifier.issn
1752-4571
dc.identifier.issn
1752-4563
dc.identifier.other
10.1111/eva.12263
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/102070
dc.identifier.doi
10.3929/ethz-b-000102070
dc.description.abstract
Many viruses significantly impact human and animal health. Understanding the population dynamics of these viruses and their hosts can provide important insights for epidemiology and virus evolution. Puumala virus (PUUV) is a European hantavirus that may cause regional outbreaks of hemorrhagic fever with renal syndrome in humans. Here, we analyzed the spatiotemporal dynamics of PUUV circulating in local populations of its rodent reservoir host, the bank vole (Myodes glareolus) during eight years. Phylogenetic and population genetic analyses of all three genome segments of PUUV showed strong geographical structuring at a very local scale. There was a high temporal turnover of virus strains in the local bank vole populations, but several virus strains persisted through multiple years. Phylodynamic analyses showed no significant changes in the local effective population sizes of PUUV, although vole numbers and virus prevalence fluctuated widely. Microsatellite data demonstrated also a temporally persisting subdivision between local vole populations, but these groups did not correspond to the subdivision in the virus strains. We conclude that restricted transmission between vole populations and genetic drift play important roles in shaping the genetic structure and temporal dynamics of PUUV in its natural host which has several implications for zoonotic risks of the human population.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
bank vole
en_US
dc.subject
genetic structure
en_US
dc.subject
hantavirus
en_US
dc.subject
host–parasite evolution
en_US
dc.subject
nephropathia epidemica
en_US
dc.subject
population dynamics
en_US
dc.subject
rodent‐borne disease
en_US
dc.subject
zoonosis
en_US
dc.title
Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2015-04-10
ethz.journal.title
Evolutionary Applications
ethz.journal.volume
8
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Evol. Appl.
ethz.pages.start
545
en_US
ethz.pages.end
559
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
006994734
ethz.publication.place
s.l.
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::09490 - Stadler, Tanja / Stadler, Tanja
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::09490 - Stadler, Tanja / Stadler, Tanja
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
ethz.date.deposited
2017-06-11T18:04:44Z
ethz.source
ECIT
ethz.identifier.importid
imp5936534766b6321512
ethz.ecitpid
pub:160194
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-15T01:32:49Z
ethz.rosetta.lastUpdated
2024-02-02T08:26:28Z
ethz.rosetta.versionExported
true
ethz.COinS
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