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dc.contributor.author
Oeder, Sebastian
dc.contributor.author
Kanashova, Tamara
dc.contributor.author
Sippula, Olli
dc.contributor.author
Sapcariu, Sean C.
dc.contributor.author
Streibel, Thorsten
dc.contributor.author
Arteaga-Salas, Jose M.
dc.contributor.author
Passig, Johannes
dc.contributor.author
Dilger, Marco
dc.contributor.author
Paur, Hanns-Rudolf
dc.contributor.author
Schlager, Christoph
dc.contributor.author
Mulhopt, Sonja
dc.contributor.author
Diabate, Silvia
dc.contributor.author
Weiss, Carsten
dc.contributor.author
Stengel, Benjamin
dc.contributor.author
Rabe, Rom
dc.contributor.author
Harndorf, Horst
dc.contributor.author
Torvela, Tiina
dc.contributor.author
Jokiniemi, Jorma K.
dc.contributor.author
Hirvonen, Maija-Riitta
dc.contributor.author
Schmidt-Weber, Carsten
dc.contributor.author
Traidl-Hoffmann, Claudia
dc.contributor.author
BéruBé, Kelly A.
dc.contributor.author
Wlodarczyk, Anna J.
dc.contributor.author
Prytherch, Zoe
dc.contributor.author
Michalke, Bernhard
dc.contributor.author
Krebs, Tobias
dc.contributor.author
Prévôt, André S.H.
dc.contributor.author
Kelbg, Michael
dc.contributor.author
Tiggesbäumker, Josef
dc.contributor.author
Karg, Erwin
dc.contributor.author
Jakobi, Gert
dc.contributor.author
Scholtes, Sorana
dc.contributor.author
Schnelle-Kreis, Jürgen
dc.contributor.author
Lintelmann, Jutta
dc.contributor.author
Matuschek, Georg
dc.contributor.author
Sklorz, Martin
dc.contributor.author
Klingbeil, Sophie
dc.contributor.author
Orasche, Jürgen
dc.contributor.author
Richthammer, Patrick
dc.contributor.author
Müller, Laarnie
dc.contributor.author
Elsasser, Michael
dc.contributor.author
Reda, Ahmed
dc.contributor.author
Gröger, Thomas
dc.contributor.author
Weggler, Benedikt
dc.contributor.author
Schwemer, Theo
dc.contributor.author
Czech, Hendryk
dc.contributor.author
Rüger, Christopher P.
dc.contributor.author
Abbaszade, Gülcin
dc.contributor.author
Radischat, Christian
dc.contributor.author
Hiller, Karsten
dc.contributor.author
Buters, Jeroen T.M.
dc.contributor.author
Dittmar, Gunnar
dc.contributor.author
Zimmermann, Ralf
dc.date.accessioned
2018-08-16T08:38:00Z
dc.date.available
2017-06-11T18:11:14Z
dc.date.available
2018-08-16T08:38:00Z
dc.date.issued
2015-06-03
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0126536
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/102225
dc.identifier.doi
10.3929/ethz-b-000102225
dc.description.abstract
Background Ship engine emissions are important with regard to lung and cardiovascular diseases especially in coastal regions worldwide. Known cellular responses to combustion particles include oxidative stress and inflammatory signalling. Objectives To provide a molecular link between the chemical and physical characteristics of ship emission particles and the cellular responses they elicit and to identify potentially harmful fractions in shipping emission aerosols. Methods Through an air-liquid interface exposure system, we exposed human lung cells under realistic in vitro conditions to exhaust fumes from a ship engine running on either common heavy fuel oil (HFO) or cleaner-burning diesel fuel (DF). Advanced chemical analyses of the exhaust aerosols were combined with transcriptional, proteomic and metabolomic profiling including isotope labelling methods to characterise the lung cell responses. Results The HFO emissions contained high concentrations of toxic compounds such as metals and polycyclic aromatic hydrocarbon, and were higher in particle mass. These compounds were lower in DF emissions, which in turn had higher concentrations of elemental carbon (“soot”). Common cellular reactions included cellular stress responses and endocytosis. Reactions to HFO emissions were dominated by oxidative stress and inflammatory responses, whereas DF emissions induced generally a broader biological response than HFO emissions and affected essential cellular pathways such as energy metabolism, protein synthesis, and chromatin modification. Conclusions Despite a lower content of known toxic compounds, combustion particles from the clean shipping fuel DF influenced several essential pathways of lung cell metabolism more strongly than particles from the unrefined fuel HFO. This might be attributable to a higher soot content in DF. Thus the role of diesel soot, which is a known carcinogen in acute air pollution-induced health effects should be further investigated. For the use of HFO and DF we recommend a reduction of carbonaceous soot in the ship emissions by implementation of filtration devices.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Particulate Matter from Both Heavy Fuel Oil and Diesel Fuel Shipping Emissions Show Strong Biological Effects on Human Lung Cells at Realistic and Comparable In Vitro Exposure Conditions
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
PLoS ONE
ethz.journal.volume
10
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e0126536
en_US
ethz.size
17 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
006206116
ethz.publication.place
S.l.
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T18:11:47Z
ethz.source
ECIT
ethz.identifier.importid
imp5936534b6d41256098
ethz.ecitpid
pub:160353
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T14:53:22Z
ethz.rosetta.lastUpdated
2018-08-16T08:38:08Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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