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dc.contributor.author
Aspelund, Aleksanteri
dc.contributor.author
Antila, Salli
dc.contributor.author
Proulx, Steven T.
dc.contributor.author
Karlsen, Tine V.
dc.contributor.author
Karaman, Sinem
dc.contributor.author
Detmar, Michael
dc.contributor.author
Wiig, Helge
dc.contributor.author
Alitalo, Kari
dc.date.accessioned
2024-07-08T14:56:00Z
dc.date.available
2017-06-11T18:14:54Z
dc.date.available
2024-07-08T14:56:00Z
dc.date.issued
2015-06-29
dc.identifier.issn
0022-1007
dc.identifier.issn
1540-0069
dc.identifier.issn
1540-9538
dc.identifier.other
10.1084/jem.20142290
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/102337
dc.identifier.doi
10.3929/ethz-b-000102337
dc.description.abstract
The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature. Yet, part of the cerebrospinal fluid (CSF) drains into the cervical lymph nodes (LNs). The mechanism of CSF entry into the LNs has been unclear. Here we report the surprising finding of a lymphatic vessel network in the dura mater of the mouse brain. We show that dural lymphatic vessels absorb CSF from the adjacent subarachnoid space and brain interstitial fluid (ISF) via the glymphatic system. Dural lymphatic vessels transport fluid into deep cervical LNs (dcLNs) via foramina at the base of the skull. In a transgenic mouse model expressing a VEGF-C/D trap and displaying complete aplasia of the dural lymphatic vessels, macromolecule clearance from the brain was attenuated and transport from the subarachnoid space into dcLNs was abrogated. Surprisingly, brain ISF pressure and water content were unaffected. Overall, these findings indicate that the mechanism of CSF flow into the dcLNs is directly via an adjacent dural lymphatic network, which may be important for the clearance of macromolecules from the brain. Importantly, these results call for a reexamination of the role of the lymphatic system in CNS physiology and disease.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Rockefeller University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.title
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
dc.date.published
2015-06-15
ethz.journal.title
Journal of Experimental Medicine
ethz.journal.volume
212
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
J Exp Med
ethz.pages.start
991
en_US
ethz.pages.end
999
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
000986015
ethz.publication.place
New York, NY
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael (emeritus) / Detmar, Michael (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael (emeritus) / Detmar, Michael (emeritus)
ethz.date.deposited
2017-06-11T18:15:23Z
ethz.source
ECIT
ethz.identifier.importid
imp5936534de66c942436
ethz.ecitpid
pub:160468
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-31T15:23:25Z
ethz.rosetta.lastUpdated
2022-03-28T13:58:11Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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