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dc.contributor.author
Krol, Jacek
dc.contributor.author
Krol, Ilona
dc.contributor.author
Patino Alvarez, Claudia P.
dc.contributor.author
Fiscella, Michele
dc.contributor.author
Hierlemann, Andreas
dc.contributor.author
Roska, Botond
dc.contributor.author
Filipowicz, Witold
dc.date.accessioned
2018-09-12T15:02:26Z
dc.date.available
2017-06-11T18:23:33Z
dc.date.available
2018-09-12T15:02:26Z
dc.date.issued
2015
dc.identifier.issn
2041-1723
dc.identifier.other
10.1038/ncomms8305
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/102533
dc.identifier.doi
10.3929/ethz-b-000102533
dc.description.abstract
Brain regions, such as the cortex and retina, are composed of layers of uniform thickness. The molecular mechanism that controls this uniformity is not well understood. Here we show that during mouse postnatal development the timed expression of Rncr4, a retina-specific long noncoding RNA, regulates the similarly timed processing of pri-miR-183/96/182, which is repressed at an earlier developmental stage by RNA helicase Ddx3x. Shifting the timing of mature miR-183/96/182 accumulation or interfering with Ddx3x expression leads to the disorganization of retinal architecture, with the photoreceptor layer being most affected. We identify Crb1, a component of the adhesion belt between glial and photoreceptor cells, as a link between Rncr4-regulated miRNA metabolism and uniform retina layering. Our results suggest that the precise timing of glia–neuron interaction controlled by noncoding RNAs and Ddx3x is important for the even distribution of cells across layers.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2015-06-04
ethz.journal.title
Nature Communications
ethz.journal.volume
6
en_US
ethz.journal.abbreviated
Nat Commun
ethz.pages.start
7305
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
007044158
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
ethz.date.deposited
2017-06-11T18:24:04Z
ethz.source
ECIT
ethz.identifier.importid
imp59365352af75351188
ethz.ecitpid
pub:160673
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-19T11:17:33Z
ethz.rosetta.lastUpdated
2020-02-15T15:01:13Z
ethz.rosetta.versionExported
true
ethz.COinS
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