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dc.contributor.author
Park, C. Sehwan
dc.contributor.author
Valomon, Amandine
dc.contributor.author
Welzl, Hans
dc.date.accessioned
2018-10-18T07:50:46Z
dc.date.available
2017-06-11T18:23:49Z
dc.date.available
2018-10-18T07:50:46Z
dc.date.issued
2015-06-23
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0130891
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/102557
dc.identifier.doi
10.3929/ethz-b-000102557
dc.description.abstract
Environmental enrichment has been reported to delay or restore age-related cognitive deficits, however, a mechanism to account for the cause and progression of normal cognitive decline and its preservation by environmental enrichment is lacking. Using genome-wide SAGE-Seq, we provide a global assessment of differentially expressed genes altered with age and environmental enrichment in the hippocampus. Qualitative and quantitative proteomics in naïve young and aged mice was used to further identify phosphorylated proteins differentially expressed with age. We found that increased expression of endogenous protein phosphatase-1 inhibitors in aged mice may be characteristic of long-term environmental enrichment and improved cognitive status. As such, hippocampus-dependent performances in spatial, recognition, and associative memories, which are sensitive to aging, were preserved by environmental enrichment and accompanied by decreased protein phosphatase activity. Age-associated phosphorylated proteins were also found to correspond to the functional categories of age-associated genes identified through transcriptome analysis. Together, this study provides a comprehensive map of the transcriptome and proteome in the aging brain, and elucidates endogenous protein phosphatase-1 inhibition as a potential means through which environmental enrichment may ameliorate age-related cognitive deficits.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Integrative Transcriptome Profiling of Cognitive Aging and Its Preservation through Ser/Thr Protein Phosphatase Regulation
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
PLoS ONE
ethz.journal.volume
10
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e0130891
en_US
ethz.size
23 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
006206116
ethz.publication.place
San Francisco, CA, USA
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T18:24:04Z
ethz.source
ECIT
ethz.identifier.importid
imp5936535351f1b71992
ethz.ecitpid
pub:160697
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-20T13:37:58Z
ethz.rosetta.lastUpdated
2018-10-18T07:50:51Z
ethz.rosetta.versionExported
true
ethz.COinS
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