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dc.contributor.author
Shine, Richard
dc.contributor.author
Amiel, Joshua
dc.contributor.author
Munn, Adam J.
dc.contributor.author
Stewart, Mathew
dc.contributor.author
Vyssotski, Alexei L.
dc.contributor.author
Lesku, John A.
dc.date.accessioned
2019-09-06T09:32:51Z
dc.date.available
2017-06-11T18:42:08Z
dc.date.available
2019-09-06T09:32:51Z
dc.date.issued
2015-07-15
dc.identifier.issn
2046-6390
dc.identifier.other
10.1242/bio.012179
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/103089
dc.identifier.doi
10.3929/ethz-b-000103089
dc.description.abstract
What is the most humane way to kill amphibians and small reptiles that are used in research? Historically, such animals were often killed by cooling followed by freezing, but this method was outlawed by ethics committees because of concerns that ice-crystals may form in peripheral tissues while the animal is still conscious, putatively causing intense pain. This argument relies on assumptions about the capacity of such animals to feel pain, the thermal thresholds for tissue freezing, the temperature-dependence of nerve-impulse transmission and brain activity, and the magnitude of thermal differentials within the bodies of rapidly-cooling animals. A review of published studies casts doubt on those assumptions, and our laboratory experiments on cane toads (Rhinella marina) show that brain activity declines smoothly during freezing, with no indication of pain perception. Thus, cooling followed by freezing can offer a humane method of killing cane toads, and may be widely applicable to other ectotherms (especially, small species that are rarely active at low body temperatures). More generally, many animal-ethics regulations have little empirical basis, and research on this topic is urgently required in order to reduce animal suffering.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Company of Biologists
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject
Animal welfare
en_US
dc.subject
Bufo marinus
en_US
dc.subject
Ectothermy
en_US
dc.subject
Evidence-based practice
en_US
dc.title
Is "cooling then freezing" a humane way to kill amphibians and reptiles?
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
dc.date.published
2016-05-26
ethz.journal.title
Biology Open
ethz.journal.volume
4
en_US
ethz.journal.issue
7
en_US
ethz.pages.start
760
en_US
ethz.pages.end
763
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
009788219
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02533 - Institut für Neuroinformatik / Institute of Neuroinformatics::03774 - Hahnloser, Richard H.R. / Hahnloser, Richard H.R.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02533 - Institut für Neuroinformatik / Institute of Neuroinformatics::03774 - Hahnloser, Richard H.R. / Hahnloser, Richard H.R.
ethz.date.deposited
2017-06-11T18:42:59Z
ethz.source
ECIT
ethz.identifier.importid
imp5936535f8496548925
ethz.ecitpid
pub:161280
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T14:35:29Z
ethz.rosetta.lastUpdated
2019-09-06T09:33:00Z
ethz.rosetta.versionExported
true
ethz.COinS
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