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dc.contributor.author
Shu, Longfei
dc.contributor.author
Laurila, Anssi
dc.contributor.author
Räsänen, Katja
dc.date.accessioned
2018-10-12T14:59:42Z
dc.date.available
2017-06-11T19:39:13Z
dc.date.available
2018-10-12T14:59:42Z
dc.date.issued
2015-09-18
dc.identifier.issn
2045-2322
dc.identifier.other
10.1038/srep14201
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/104796
dc.identifier.doi
10.3929/ethz-b-000104796
dc.description.abstract
Ion channels and pumps are responsible for ion flux in cells, and are key mechanisms mediating cellular function. Many environmental stressors, such as salinity and acidification, are known to severely disrupt ionic balance of organisms thereby challenging fitness of natural populations. Although ion channels can have several vital functions during early life-stages (e.g. embryogenesis), it is currently not known i) how developing embryos maintain proper intracellular conditions when exposed to environmental stress and ii) to what extent environmental stress can drive intra-specific divergence in ion channels. Here we studied the moor frog, Rana arvalis, from three divergent populations to investigate the role of different ion channels and pumps for embryonic survival under acid stress (pH 4 vs 7.5) and whether populations adapted to contrasting acidities differ in the relative role of different ion channel/pumps. We found that ion channels that mediate Ca2+ influx are essential for embryonic survival under acidic pH, and, intriguingly, that populations differ in calcium channel function. Our results suggest that adaptive divergence in embryonic acid stress tolerance of amphibians may in part be mediated by Ca2+ balance. We suggest that ion flux may mediate adaptive divergence of natural populations at early life-stages in the face of environmental stress.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Evolutionary developmental biology
en_US
dc.subject
Climate-change ecology
en_US
dc.title
Acid stress mediated adaptive divergence in ion channel function during embryogenesis in Rana arvalis
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Scientific Reports
ethz.journal.volume
5
en_US
ethz.journal.abbreviated
Sci Rep
ethz.pages.start
14201
en_US
ethz.size
9 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
006751867
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T19:39:52Z
ethz.source
ECIT
ethz.identifier.importid
imp593653852899813571
ethz.ecitpid
pub:164078
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T15:05:47Z
ethz.rosetta.lastUpdated
2024-02-02T06:20:39Z
ethz.rosetta.versionExported
true
ethz.COinS
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