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dc.contributor.author
Gökbuget, Deniz
dc.contributor.author
Pereira, Jorge A.
dc.contributor.author
Bachofner, Sven
dc.contributor.author
Marchais, Antonin
dc.contributor.author
Ciaudo, Constance
dc.contributor.author
Stoffel, Markus
dc.contributor.author
Schulte, Johannes H.
dc.contributor.author
Suter, Ueli
dc.date.accessioned
2018-09-13T14:55:19Z
dc.date.available
2017-06-11T20:18:29Z
dc.date.available
2018-09-13T14:53:07Z
dc.date.available
2018-09-13T14:55:19Z
dc.date.issued
2015
dc.identifier.issn
2041-1723
dc.identifier.other
10.1038/ncomms9584
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/105752
dc.identifier.doi
10.3929/ethz-b-000105752
dc.description.abstract
MicroRNAs (miRNAs) are crucial regulators of myelination in the peripheral nervous system (PNS). However, the miRNAs species involved and the underlying mechanisms are largely unknown. We found that let-7 miRNAs are highly abundant during PNS myelination and that their levels are inversely correlated to the expression of lin28 homolog B (Lin28B), an antagonist of let-7 accumulation. Sustained expression of Lin28B and consequently reduced levels of let-7 miRNAs results in a failure of Schwann cell myelination in transgenic mouse models and in cell culture. Subsequent analyses revealed that let-7 miRNAs promote expression of the myelination-driving master transcription factor Krox20 (also known as Egr2) through suppression of myelination inhibitory Notch signalling. We conclude that the Lin28B/let-7 axis acts as a critical driver of PNS myelination, in particular by regulating myelination onset, identifying this pathway also as a potential therapeutic target in demyelinating diseases.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
The Lin28/let-7 axis is critical for myelination in the peripheral nervous system
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2015-10-14
ethz.journal.title
Nature Communications
ethz.journal.volume
6
en_US
ethz.journal.abbreviated
Nat Commun
ethz.pages.start
8584
en_US
ethz.size
9 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
007044158
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03983 - Ciaudo, Constance / Ciaudo, Constance
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03739 - Stoffel, Markus / Stoffel, Markus
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03367 - Suter, Ulrich / Suter, Ulrich
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03983 - Ciaudo, Constance / Ciaudo, Constance
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03739 - Stoffel, Markus / Stoffel, Markus
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03367 - Suter, Ulrich / Suter, Ulrich
ethz.date.deposited
2017-06-11T20:19:27Z
ethz.source
ECIT
ethz.identifier.importid
imp593653992c12993193
ethz.ecitpid
pub:165545
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T11:19:33Z
ethz.rosetta.lastUpdated
2020-02-15T15:02:55Z
ethz.rosetta.versionExported
true
ethz.COinS
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