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dc.contributor.author
Thom, Jenny T.
dc.contributor.author
Weber, Thomas C.
dc.contributor.author
Walton, Senta M.
dc.contributor.author
Torti, Nicole
dc.contributor.author
Oxenius, Annette
dc.date.accessioned
2018-09-25T13:09:39Z
dc.date.available
2017-06-11T20:29:56Z
dc.date.available
2018-09-25T13:09:39Z
dc.date.issued
2015-11
dc.identifier.issn
2666-3864
dc.identifier.issn
2211-1247
dc.identifier.other
10.1016/j.celrep.2015.09.082
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/106148
dc.identifier.doi
10.3929/ethz-b-000106148
dc.description.abstract
Tissue-resident memory T cells (TRM) reside in barrier tissues and provide local immediate protective immunity. Here, we show that the salivary gland (SG) most-effectively induces CD8+ and CD4+ TRM cells against murine cytomegalovirus (MCMV), which persists in and spreads from this organ. TRM generation depended on local antigen for CD4+, but not CD8+, TRM cells, highlighting major differences in T cell subset-specific demands for TRM development. CMV-specific CD8+ T cells fail to control virus replication upon primary infection in the SG due to CMV-induced MHC I downregulation in glandular epithelial cells. Using intraglandular infection, we challenge this notion and demonstrate that memory CD8+ T cells confer immediate protection against locally introduced MCMV despite active viral immune evasion, owing to early viral tropism to cells that largely withstand MHC I downregulation. Thus, we unravel a yet-unappreciated role for memory CD8+ T cells in protecting mucosal tissues against CMV infection.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
The Salivary Gland Acts as a Sink for Tissue-Resident Memory CD8+ T Cells, Facilitating Protection from Local Cytomegalovirus Infection
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2015-10-29
ethz.journal.title
Cell Reports
ethz.journal.volume
13
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Cell Rep
ethz.pages.start
1125
en_US
ethz.pages.end
1136
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Regulation of adaptive immunity during acute and persistent viral infections
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
007612702
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::03625 - Oxenius, Annette / Oxenius, Annette
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::03625 - Oxenius, Annette / Oxenius, Annette
ethz.grant.agreementno
146140
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.date.deposited
2017-06-11T20:30:53Z
ethz.source
ECIT
ethz.identifier.importid
imp593653a144e3d60030
ethz.ecitpid
pub:166109
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-15T04:53:17Z
ethz.rosetta.lastUpdated
2022-03-28T21:22:14Z
ethz.rosetta.versionExported
true
ethz.COinS
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