CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer

Open access
Author
Show all
Date
2015Type
- Journal Article
Citations
Cited 28 times in
Web of Science
Cited 30 times in
Scopus
ETH Bibliography
yes
Altmetrics
Abstract
Aims. CD73 is a membrane associated 5′-ectonucleotidase that has been proposed as prognostic biomarker in various solid tumors. The aim of this study is to evaluate CD73 expression in a cohort of patients with primary bladder cancer in regard to its association with clinicopathological features and disease course. Methods. Tissue samples from 174 patients with a primary urothelial carcinoma were immunohistochemically assessed on a tissue microarray. Associations between CD73 expression and retrospectively obtained clinicopathological data were evaluated by contingency analysis. Survival analysis was performed to investigate the predictive value of CD73 within the subgroup of pTa and pT1 tumors in regard to progression-free survival (PFS). Results. High CD73 expression was found in 46 (26.4%) patients and was significantly associated with lower stage, lower grade, less adjacent carcinoma in situ and with lower Ki-67 proliferation index. High CD73 immunoreactivity in the subgroup of pTa and pT1 tumors was significantly associated with longer PFS (HR: 0.228; ) in univariable Cox regression analysis. Conclusion. High CD73 immunoreactivity was associated with favorable clinicopathological features. Furthermore, it predicts better outcome in the subgroup of pTa and pT1 tumors and may thus serve as additional tool for the selection of patients with favorable prognosis. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000106212Publication status
publishedExternal links
Journal / series
Disease MarkersVolume
Pages / Article No.
Publisher
IOS PressMore
Show all metadata
Citations
Cited 28 times in
Web of Science
Cited 30 times in
Scopus
ETH Bibliography
yes
Altmetrics