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dc.contributor.author
Dieterich, Lothar C.
dc.contributor.author
Klein, Sarah
dc.contributor.author
Mathelier, Anthony
dc.contributor.author
Sliwa-Primorac, Adriana
dc.contributor.author
Ma, Qiaoli
dc.contributor.author
Hong, Young-Kwon
dc.contributor.author
Shin, Jay W.
dc.contributor.author
Hamada, Michito
dc.contributor.author
Lizio, Marina
dc.contributor.author
Itoh, Masayoshi
dc.contributor.author
Kawaji, Hideya
dc.contributor.author
Lassmann, Timo
dc.contributor.author
Daub, Carsten O.
dc.contributor.author
Arner, Erik
dc.contributor.author
Carninci, Piero
dc.contributor.author
Hayashizaki, Yoshihide
dc.contributor.author
Forrest, Alistair R.R.
dc.contributor.author
Wasserman, Wyeth W.
dc.contributor.author
Detmar, Michael
dc.date.accessioned
2018-09-19T11:19:46Z
dc.date.available
2017-06-11T21:10:27Z
dc.date.available
2018-09-19T11:19:46Z
dc.date.issued
2015-11
dc.identifier.other
10.1016/j.celrep.2015.10.002
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/106898
dc.identifier.doi
10.3929/ethz-b-000106898
dc.description.abstract
VEGF-C/VEGFR-3 signaling plays a central role in lymphatic development, regulating the budding of lymphatic progenitor cells from embryonic veins and maintaining the expression of PROX1 during later developmental stages. However, how VEGFR-3 activation translates into target gene expression is still not completely understood. We used cap analysis of gene expression (CAGE) RNA sequencing to characterize the transcriptional changes invoked by VEGF-C in LECs and to identify the transcription factors (TFs) involved. We found that MAFB, a TF involved in differentiation of various cell types, is rapidly induced and activated by VEGF-C. MAFB induced expression of PROX1 as well as other TFs and markers of differentiated LECs, indicating a role in the maintenance of the mature LEC phenotype. Correspondingly, E14.5 Mafb−/− embryos showed impaired lymphatic patterning in the skin. This suggests that MAFB is an important TF involved in lymphangiogenesis.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2015-11-05
ethz.journal.title
Cell Reports
ethz.journal.volume
13
en_US
ethz.journal.issue
7
en_US
ethz.pages.start
1493
en_US
ethz.pages.end
1504
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Molecular mechanisms of angiogenesis and lymphangiogenesis in inflammation and cancer progression
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
007612702
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael / Detmar, Michael
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael / Detmar, Michael
ethz.grant.agreementno
147087
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Bonus of Excellence
ethz.date.deposited
2017-06-11T21:10:47Z
ethz.source
ECIT
ethz.identifier.importid
imp593653b06d60f72767
ethz.ecitpid
pub:167314
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-08-01T17:18:59Z
ethz.rosetta.lastUpdated
2018-11-08T02:31:57Z
ethz.rosetta.versionExported
true
ethz.COinS
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