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dc.contributor.author
Lienemann, Philipp S.
dc.contributor.author
Metzger, Stéphanie
dc.contributor.author
Kiveliö, Anna-Sofia
dc.contributor.author
Blanc, Alain
dc.contributor.author
Papageorgiou, Panagiota
dc.contributor.author
Astolfo, Alberto
dc.contributor.author
Pinzer, Bernd R.
dc.contributor.author
Cinelli, Paolo
dc.contributor.author
Weber, Franz E.
dc.contributor.author
Schibli, Roger
dc.contributor.author
Béhé, Martin
dc.contributor.author
Ehrbar, Martin
dc.date.accessioned
2018-10-11T10:54:25Z
dc.date.available
2017-06-11T22:05:12Z
dc.date.available
2018-05-31T08:59:19Z
dc.date.available
2018-10-11T10:54:25Z
dc.date.issued
2015-05-19
dc.identifier.other
10.1038/srep10238
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/108688
dc.identifier.doi
10.3929/ethz-b-000108688
dc.description.abstract
Over the last decades, great strides were made in the development of novel implants for the treatment of bone defects. The increasing versatility and complexity of these implant designs request for concurrent advances in means to assess in vivo the course of induced bone formation in preclinical models. Since its discovery, micro-computed tomography (micro-CT) has excelled as powerful high-resolution technique for non-invasive assessment of newly formed bone tissue. However, micro-CT fails to provide spatiotemporal information on biological processes ongoing during bone regeneration. Conversely, due to the versatile applicability and cost-effectiveness, single photon emission computed tomography (SPECT) would be an ideal technique for assessing such biological processes with high sensitivity and for nuclear imaging comparably high resolution (<1 mm). Herein, we employ modular designed poly(ethylene glycol)-based hydrogels that release bone morphogenetic protein to guide the healing of critical sized calvarial bone defects. By combined in vivo longitudinal multi-pinhole SPECT and micro-CT evaluations we determine the spatiotemporal course of bone formation and remodeling within this synthetic hydrogel implant. End point evaluations by high resolution micro-CT and histological evaluation confirm the value of this approach to follow and optimize bone-inducing biomaterials.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Tissue engineering
en_US
dc.subject
Molecular imaging
en_US
dc.subject
Bioinspired materials
en_US
dc.title
Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2015-05-19
ethz.journal.title
Scientific Reports
ethz.journal.volume
5
en_US
ethz.pages.start
10238
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.identifier.nebis
006751867
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
ethz.relation.isReferencedBy
10.3929/ethz-b-000108685
ethz.date.deposited
2017-06-11T22:05:30Z
ethz.source
ECIT
ethz.identifier.importid
imp593653d39a33412964
ethz.ecitpid
pub:169687
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T11:30:11Z
ethz.rosetta.lastUpdated
2019-01-02T14:26:35Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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